Research in gene therapy involving genome-integrating vectors now often includes analysis of vector integration sites across the genome using methods such as ligation-mediated PCR (LM-PCR) or linear ...

Figure 1: Workflow of genome-wide integrome studies based on nrLAM-PCR, GS FLX sample preparation and sequencing, and bioinformatical data mining. At this time, there are several commercial sequencing ...

The location of integration of a gene therapy has been crucial for the safety and efficacy of the treatment to cure infants with X-linked severe combined immunodeficiency. Identified integrome ...